Acosta A L, Rodríguez A D
Department of Chemistry, University of Puerto Rico, Río Piedras 00931.
J Nat Prod. 1992 Jul;55(7):1007-12. doi: 10.1021/np50085a031.
A new cytotoxic bromotyrosine-derived secondary metabolite, 11-oxoaerothionin [3], was isolated from the Caribbean sea sponge Aplysina lacunosa. The structure of 3 was argued on the basis of detailed spectroscopic analysis and by chemical conversion to the known antibiotic compound 11-hydroxyaerothionin [2]. When screened against a panel of four human cell lines, 11-oxoaerothionin [3] showed pronounced as well as selective antitumor activity toward the human colon (HCT 116) cell line within the limited concentration range of 0.01-0.1 microgram/ml.
一种新的细胞毒性溴酪氨酸衍生的次生代谢产物，11-氧代气硫素[3]，从加勒比海绵Aplysina lacunosa中分离得到。通过详细的光谱分析以及化学转化为已知的抗生素化合物11-羟基气硫素[2]，确定了3的结构。在针对四种人类细胞系进行筛选时，11-氧代气硫素[3]在0.01-0.1微克/毫升的有限浓度范围内，对人结肠（HCT 116）细胞系显示出显著且选择性的抗肿瘤活性。
