来自地锦全草的生物活性甾体化合物。

Bioactive steroids from the whole herb of Euphorbia chamaesyce.

作者信息

Tanaka R, Kasubuchi K, Kita S, Tokuda H, Nishino H, Matsunaga S

机构信息

Department of Medicinal Chemistry, Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan.

出版信息

J Nat Prod. 2000 Jan;63(1):99-103. doi: 10.1021/np990394b.

DOI:10.1021/np990394b

PMID:10650087

Abstract

Three new ergostane-type steroids, 3beta-hydroxy-4alpha, 14alpha-dimethyl-5alpha-ergosta-8,24(28)-dien-11 -one (1); 3beta, 11alpha-dihydroxy-4alpha,14alpha-dimethyl-5alpha -ergosta-8, 24(28)-dien-7-one (2); and 3beta,7alpha-dihydroxy-4alpha, 14alpha-dimethyl-5alpha-ergosta-8,24(28)-dien-11 -one (3), were isolated, together with two known triterpenoids, wrightial and lup-20(30)-ene-3beta,29-diol from the whole herb of Euphorbia chamaesyce. Compound 3 showed a potent inhibitory effect on Epstein-Barr virus early antigen activation induced by the tumor promoter 12-O-tetradecanoylphorbol 13-acetate (TPA).

摘要

从地锦全草中分离出三种新的麦角甾烷型甾体化合物，即3β-羟基-4α,14α-二甲基-5α-麦角甾-8,24(28)-二烯-11-酮（1）；3β,11α-二羟基-4α,14α-二甲基-5α-麦角甾-8,24(28)-二烯-7-酮（2）；以及3β,7α-二羟基-4α,14α-二甲基-5α-麦角甾-8,24(28)-二烯-11-酮（3），同时还分离出两种已知的三萜类化合物，即卫矛醇和羽扇-20(30)-烯-3β,29-二醇。化合物3对肿瘤促进剂12-O-十四酰佛波醇-13-乙酸酯（TPA）诱导的爱泼斯坦-巴尔病毒早期抗原激活具有显著的抑制作用。