Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China.
Magn Reson Chem. 2011 Jun;49(6):366-9. doi: 10.1002/mrc.2748. Epub 2011 Mar 31.
A new oxylipin, (8E,12Z)-10,11-dihydroxyoctadeca-8,12-dienoic acid (1), a new steroid, 3β,4α-dihydroxy-26-methoxyergosta-7,24(28)-dien-6-one (2), and four known steroids, episterol (3), (22E,24R)-ergosta-7,22-dien-3β,5α,6α-triol (4), (22E,24R)-ergosta-5,22-dien-3β-ol (5), and (22E,24R)-ergosta-4,6,8(14),22-tetraen-3-one (6), were isolated from the cultures of Aspergillus flavus, an endophytic fungus isolated from the marine red alga Corallina officinalis. Their structures and relative stereochemistry were elucidated by 1D, 2D NMR and mass spectroscopic techniques. 1 and 2 exhibited low activity to inhibit acetylcholinesterase and no activity against plant pathogenic fungi Colletotrichum lagenarium and Fusarium oxysporum.
一种新的氧化脂，（8E,12Z）-10,11-二羟基十八碳-8,12-二烯酸（1），一种新的甾体，3β,4α-二羟基-26-甲氧基麦角甾-7,24(28)-二烯-6-酮（2），以及四个已知的甾体，表甾醇（3），（22E,24R）-麦角甾-7,22-二烯-3β,5α,6α-三醇（4），（22E,24R）-麦角甾-5,22-二烯-3β-醇（5），和（22E,24R）-麦角甾-4,6,8(14),22-四烯-3-酮（6），从海洋红藻柳珊瑚内生真菌黄曲霉的培养物中分离得到。它们的结构和相对立体化学通过 1D、2D NMR 和质谱技术得到阐明。1 和 2 对乙酰胆碱酯酶的抑制活性较低，对植物病原菌胶孢炭疽菌和尖孢镰刀菌无活性。
