euphormin A 和 B，海桐叶中的新吡喃香豆素衍生物及其抗炎活性。

School of Pharmacy, China Medical University, Taichung 406, Taiwan.

Department of Medical Laboratory Science, College of Medical Science and Technology, I Shou University, Kaohsiung 824, Taiwan.

Molecules. 2022 Mar 14;27(6):1885. doi: 10.3390/molecules27061885.

Euphormin-A () and euphormin-B (), two new pyranocoumarin derivatives, and forty known compounds (-) were isolated from Hayata (Euphorbiaceae). The chemical structures of all compounds were established based on spectroscopic analyses. Several isolates were evaluated for their anti-inflammatory activity. Compounds , , , , , and significantly inhibited against superoxide anion generation and elastase release by human neutrophils in response to formyl-L-methionyl-L-leucyl-L-phenylalanine/cytochalasin B (fMLP/CB). Furthermore, compounds and displayed the most potent effects with IC values of 0.68 ± 0.18 and 1.39 ± 0.12 µM, respectively, against superoxide anion generation when compared with the positive control (2.01 ± 0.06 µM).

从 Hayata（大戟科）中分离得到两种新的吡喃香豆素衍生物 Euphormin-A() 和 Euphormin-B()，以及四十种已知化合物 (-)。基于光谱分析确定了所有化合物的化学结构。对几种分离物的抗炎活性进行了评估。化合物、、、、、和显著抑制了人中性粒细胞对甲酰基-L-甲硫氨酸-L-亮氨酸-L-苯丙氨酸/细胞松弛素 B（fMLP/CB）的超氧阴离子生成和弹性蛋白酶释放。此外，化合物和显示出最有效的作用，其对超氧阴离子生成的 IC 值分别为 0.68 ± 0.18 和 1.39 ± 0.12 μM，与阳性对照（2.01 ± 0.06 μM）相比。