Horgen F D, delos Santos D B, Goetz G, Sakamoto B, Kan Y, Nagai H, Scheuer P J
Department of Chemistry, University of Hawaii at Manoa, 2545 The Mall, Honolulu, Hawaii 96822, USA.
J Nat Prod. 2000 Jan;63(1):152-4. doi: 10.1021/np990402o.
A new cyclic depsipeptide, kahalalide O (1), was isolated from the sacoglossan Elysia ornata and its algal diet Bryopsis sp. The structure was elucidated primarily by NMR and MS spectral methods, and the stereochemistry of the amino acid residues was determined by chiral HPLC and Marfey analyses. Unlike the related metabolite kahalalide F, which is in development as a potential anticancer agent, kahalalide O (1) was inactive in arresting the growth of P-388, A549, HT29, and MEL28 cancer cell lines in vitro.
从裸鳃亚目动物华丽多彩海兔及其藻类食物羽藻属中分离出一种新的环缩肽——卡哈拉利德O（1）。其结构主要通过核磁共振（NMR）和质谱（MS）光谱方法阐明，氨基酸残基的立体化学通过手性高效液相色谱法（HPLC）和马尔菲分析确定。与作为潜在抗癌剂正在研发的相关代谢物卡哈拉利德F不同，卡哈拉利德O（1）在体外对P - 388、A549、HT29和MEL28癌细胞系的生长抑制无活性。
