The Department of Pharmacognosy, Pharmacology and National Center for the Development of Natural Products, School of Pharmacy, The University of Mississippi, University, Mississippi 38677, USA.
J Nat Prod. 2009 Dec;72(12):2172-6. doi: 10.1021/np900287e.
Two new cyclic depsipeptides, 5-OHKF (1) and norKA (2), together with the known congeners kahalalide F (3) and isokahalalide F ((4S)- methylhexanoic kahalalide F) (4) were isolated from the green alga Bryopsis pennata. The structures of the new compounds were established on the basis of extensive 1D and 2D NMR spectroscopic analysis and mass spectrometric (ESIMS) data. The absolute configuration of each amino acid of 5-OHKF (1) and norKA (2) was determined by chemical degradation and Marfey's analysis. The biological activities of these two compounds are also reported.
从绿藻石莼中分离得到两个新的环二肽 5-OHKF（1）和 norKA（2），以及已知的同系物 kahalalide F（3）和 isokahalalide F（（4S）-甲基己酸 kahalalide F）（4）。新化合物的结构是基于广泛的 1D 和 2D NMR 光谱分析和质谱（ESIMS）数据确定的。通过化学降解和 Marfey 分析确定了 5-OHKF（1）和 norKA（2）中每个氨基酸的绝对构型。还报告了这两种化合物的生物活性。
