Panayotacopoulou M T, Goudsmit E, Van Heerikhuize J J, Swaab D F
Department of Psychiatry, Eginition Hospital, University of Athens, 74 Vassilissis Sophias Ave., Athens, Greece.
Brain Res. 2000 Feb 7;855(1):181-5. doi: 10.1016/s0006-8993(99)02240-4.
Our purpose was to investigate the proportion of tyrosine hydroxylase (TH)-immunoreactive (IR) neurons expressing vasopressin (VP) mRNA in the human paraventricular and supraoptic nuclei by combining in situ hybridization with immunohistochemistry on the same tissue section. A variability in the proportion of TH-IR neurons synthesizing VP mRNA was observed in adults which was usually more than 50%. In neonates almost all the TH-IR neurons appeared to contain VP mRNA.
我们的目的是通过在同一组织切片上结合原位杂交与免疫组织化学，研究人室旁核和视上核中表达血管加压素（VP）mRNA的酪氨酸羟化酶（TH）免疫反应性（IR）神经元的比例。在成年人中观察到合成VP mRNA的TH-IR神经元比例存在差异，通常超过50%。在新生儿中，几乎所有TH-IR神经元似乎都含有VP mRNA。
