Colović M, Hadzi-Djokić J, Cemerikić V, Colović R, Janković G, Dacić M
Institute of Haematology, Clinical Center of Serbia, Belgrade, Yugoslavia.
Hematol Cell Ther. 1999 Nov;41(5):229-32. doi: 10.1007/s00282-999-0229-x.
A primary mucosa associated lymphoid tissue tumor (MALT) of the kidney in a 50-year-old man who suffered from on therapy resistant high blood pressure over 15 years period is presented. A mass in the right kidney (6x5x3 cm) during routine check up was discovered on ultrasonography and confirmed on CT scan and NMR. The patient was submitted to nephrectomy. A mass involving kidney, pyelon and upper part of the ureter was found. Histology showed low grade non-Hodgkin B-cell lymphoma of MALT type. The neoplastic cells were positive for monoclonal antibodies CD20, CD79alpha, surface and cytoplasmic and IgM immunoglobulins and showed light chain restriction (kappa+). After histology was available, a careful staging was performed. The disease was not found anywhere else. It was concluded that the patient belonged to the stage IE of primary kidney MALT lymphoma. Gastroscopy showed signs of chronic superficial gastritis. Urease test was positive and IgG antibodies against Helicobacter pylori in titer 421 were found as well. Except for Helicobacter pylori no additional therapy was given.
本文报告了一名50岁男性患者，患有超过15年的治疗抵抗性高血压，其肾脏出现原发性黏膜相关淋巴组织肿瘤（MALT）。在常规检查中，超声检查发现右肾有一个肿块（6×5×3 cm），CT扫描和核磁共振成像（NMR）证实了这一发现。患者接受了肾切除术。术中发现一个累及肾脏、肾盂和输尿管上段的肿块。组织学检查显示为MALT型低级别非霍奇金B细胞淋巴瘤。肿瘤细胞对单克隆抗体CD20、CD79α、表面和细胞质以及IgM免疫球蛋白呈阳性，并显示轻链限制（kappa+）。组织学检查结果出来后，进行了仔细的分期。未在其他任何部位发现该疾病。结论是该患者属于原发性肾脏MALT淋巴瘤的IE期。胃镜检查显示有慢性浅表性胃炎的迹象。尿素酶试验呈阳性，还发现抗幽门螺杆菌IgG抗体滴度为421。除幽门螺杆菌外，未给予其他治疗。
