Division of Nephrology, Univeristy of Toledo College of Medicine, 3000 Arlington Avenue, Mail Stop 1186, Toledo, OH 43614-2598, USA.
Int Urol Nephrol. 2012 Dec;44(6):1911-3. doi: 10.1007/s11255-011-9992-z. Epub 2011 May 20.
Low-grade Extranodal Marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue, a subtype of non-Hodgkin's Lymphoma, involving the kidney is a rare clinical entity. Association of Minimal change disease nephrotic range proteinuria with Hodgkin's lymphoma is well described, however is extremely uncommon with non-Hodgkin's lymphoma. We describe a patient who presented with nephrotic syndrome and a kidney biopsy revealed marginal zone lymphoma and diffuse epithelial foot process effacement. He showed dramatic response to a combination therapy with cyclophosphamide, corticosteroids, and Rituximab.
黏膜相关淋巴组织的低级结外边缘区 B 细胞淋巴瘤，非霍奇金淋巴瘤的一个亚型，累及肾脏是一种罕见的临床实体。霍奇金淋巴瘤患者常伴有微小病变性肾病范围蛋白尿，而非霍奇金淋巴瘤则非常罕见。我们描述了一位以肾病综合征就诊的患者，肾活检显示边缘区淋巴瘤和弥漫性上皮足突消失。他对环磷酰胺、皮质类固醇和利妥昔单抗联合治疗有显著反应。
