Goldberg M, Harel A, Gruenbaum Y
Department of Genetics, The Institute of Life Sciences, The Hebrew University of Jerusalem, Israel.
Crit Rev Eukaryot Gene Expr. 1999;9(3-4):285-93. doi: 10.1615/critreveukargeneexpr.v9.i3-4.130.
The nuclear lamina is located between the inner nuclear membrane and the peripheral chromatin. It is composed mainly of nuclear lamins and lamina-associated proteins. The nuclear lamina is involved in nuclear organization, cell cycle regulation, and differentiation. As such, impairment in its architecture and/or function leads to genetic diseases and apoptosis. This article describes the molecular organization of the nuclear lamins, their assembly into filaments, their distribution within the nucleus, and the complex network of interactions between them and other proteins of the inner nuclear membrane. Recent findings unraveled evidence for specific interactions between proteins of the nuclear lamina and the chromatin. These include interactions between nuclear lamins and core histones, Lamina Associated Polypeptide 2 (LAP2), and the Barrier to Autointegration Factor (BAF) and interactions between lamin B receptor (LBR) and the chromodomain protein HP1. Taken together, these studies attribute a role for both the nuclear lamins and the lamina-associated proteins, LAP2 and LBR, in nuclear organization and nuclear assembly.
核纤层位于内核膜和外周染色质之间。它主要由核纤层蛋白和核纤层相关蛋白组成。核纤层参与细胞核组织、细胞周期调控和分化。因此，其结构和/或功能的损伤会导致遗传疾病和细胞凋亡。本文描述了核纤层蛋白的分子组织、它们组装成细丝的过程、它们在细胞核内的分布，以及它们与内核膜其他蛋白质之间复杂的相互作用网络。最近的研究揭示了核纤层蛋白与染色质之间特定相互作用的证据。这些相互作用包括核纤层蛋白与核心组蛋白、核纤层相关多肽2（LAP2）和自身整合障碍因子（BAF）之间的相互作用，以及核纤层B受体（LBR）与染色体结构域蛋白HP1之间的相互作用。综上所述，这些研究表明核纤层蛋白以及核纤层相关蛋白LAP2和LBR在细胞核组织和核组装中发挥作用。
