Hill L, Holdsworth D, Small R
P N G Med J. 1976 Sep;18(3):157-61.
This study reports some biological studies on the alkaloid virosecurinine isolated from the plant Securinega Virosa. Virosecurinine is an isomer of the securinine group of alkaloids present in plants used in traditional medicines in many areas, including the Central District of Papua New Guinea. Virosecurinine is mildly toxic to mice with an LD50 of 73 milligrams per kilogram body weight. Death results from violent tonic convulsions and paralysis similar to those observed with strychnine poisoning. Virosecurinine had no effect on the growth of the following bacteria, E. coli, S. aureus, and B. subtilis, or the fungi, F. monoliforme, P. viridicatum, A. niger, R. solani, R. stolonifer and C. lunata.
本研究报告了对从植物一叶萩（Securinega Virosa）中分离出的生物碱一叶萩碱乙的一些生物学研究。一叶萩碱乙是一叶萩碱类生物碱的异构体，存在于包括巴布亚新几内亚中区在内的许多地区传统药物所用的植物中。一叶萩碱乙对小鼠有轻度毒性，半数致死量为每千克体重73毫克。死亡是由剧烈的强直性惊厥和麻痹导致的，类似于士的宁中毒所观察到的症状。一叶萩碱乙对以下细菌，即大肠杆菌、金黄色葡萄球菌和枯草芽孢杆菌，以及对真菌，即串珠镰刀菌、绿青霉、黑曲霉、茄丝核菌、匍枝根霉和新月弯孢霉的生长均无影响。
