Tatematsu H, Mori M, Yang T H, Chang J J, Lee T T, Lee K H
Division of Medicinal Chemistry and Natural Products, School of Pharmacy, University of North Carolina, Chapel Hill 27599.
J Pharm Sci. 1991 Apr;80(4):325-7. doi: 10.1002/jps.2600800408.
Virosecurinine (1) and viroallosecurinine (2) were isolated as two cytotoxic alkaloids from the leaves of Securinega virosa. A comparison of the cytotoxicity of 1 and several of its derivatives indicates that an alpha,beta- and a gamma,delta-unsaturated lactone located in a strained ring system, such as rings -B, -C, and -D of 1, is structurally required for significant cytotoxicity.
从黄蝉叶中分离出了两种具有细胞毒性的生物碱，即维罗千里光宁（1）和维罗别异千里光宁（2）。对1及其几种衍生物的细胞毒性进行比较表明，位于如1的B、C和D环等张力环系统中的α,β-和γ,δ-不饱和内酯，在结构上是产生显著细胞毒性所必需的。
