Anthony A, Pounder R E, Dhillon A P, Wakefield A J
Departments of Histopathology and Medicine, Royal Free and University College Medical School, London, UK.
Aliment Pharmacol Ther. 2000 Feb;14(2):241-5. doi: 10.1046/j.1365-2036.2000.00694.x.
Both Crohn's disease ileal ulcers and indomethacin-induced jejunal ulcers in the rat have a predilection for the mesenteric margin of the bowel wall. Unlike the anti-mesenteric margin, the mesenteric margin is supplied by small end-arteries that might render it more sensitive to ischaemic injury.
To examine, in both situations, the histological relationship between the precise localization of small bowel ulcers and the mesenteric margin.
Ileal Crohn's disease ulcers identified in surgical resection specimens (n=5) and indomethacin-induced lesions in the rat jejunum (n=6) were examined macroscopically and histologically.
In both the human ileum and the rat jejunum, ulcers occurred consistently along the mesenteric margin, with the most extensive mucosal injury occurring at two adjacent sites on either side of the midline of this margin. At these two sites, feeding arteries entered the muscularis propria.
For anatomical reasons apparently related to the vasculature of the human and rodent small bowel, specific sites along the mesenteric margin are susceptible to Crohn's disease ulceration and NSAID damage, respectively.
克罗恩病的回肠溃疡和大鼠吲哚美辛诱导的空肠溃疡都好发于肠壁的肠系膜缘。与对系膜缘不同，肠系膜缘由小终末动脉供血，这可能使其对缺血性损伤更敏感。
在这两种情况下，研究小肠溃疡的精确定位与肠系膜缘之间的组织学关系。
对手术切除标本中确定的回肠克罗恩病溃疡（n = 5）和大鼠空肠中吲哚美辛诱导的病变（n = 6）进行大体和组织学检查。
在人回肠和大鼠空肠中，溃疡均始终沿着肠系膜缘发生，在该边缘中线两侧的两个相邻部位出现最广泛的黏膜损伤。在这两个部位，供血动脉进入固有肌层。
由于明显与人及啮齿动物小肠血管系统相关的解剖学原因，肠系膜缘的特定部位分别易患克罗恩病溃疡和非甾体抗炎药损伤。
