Ueda S, Isoda M, Imayama S
Ueda Setsuko Clinic, *Tenjin Clinic and Department of Dermatology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Br J Dermatol. 2000 Jan;142(1):77-83. doi: 10.1046/j.1365-2133.2000.03264.x.
Lesions of naevus of Ota range in colour from light brown to blue, and even greenish-black. To develop guidelines for optimal treatment, we evaluated the number of Q-switched ruby laser treatments required to eliminate the pigmentation of such lesions classified by colour. Over a period of 6 years, we evaluated 151 Japanese patients with naevus of Ota who had been treated with the Q-switched ruby laser at a low energy level (wavelength 694.3 nm; pulse duration 28 x 10-9 s; energy fluence 5 J/cm2; spot size 6.5 mm) every 2 months. Each lesion was classified by colour as brown (n = 22), brown-violet (n = 42), violet-blue (n = 81) and blue-green (n = 6). The 22 predominantly brown lesions attained an excellent (100-95%) or good (95-75%) cosmetic result following three laser treatments in all patients who received this number of treatments. In the 42 brown-violet lesions, 25 of the 29 good or excellent results were achieved after four treatments; the 13 less successful results were in patients who had one to three treatments. In the 81 violet-blue lesions, 54 of the 65 good or excellent results were achieved after four treatments and 64 of 65 after five treatments, whereas all 16 less good results were in patients who had only one to three treatments. However, in the six blue-green lesions, six or more treatments were required to achieve a similarly favourable result. At the end of treatment, the area was virtually free of scarring, and its texture resembled that of the surrounding normal skin. We have confirmed that the use of the Q-switched ruby laser at a low energy level can eliminate the pigmentation of naevus of Ota. While the desired improvement can be obtained within 1 year, the number of treatments appears to depend on the predominant colour of the lesion.
太田痣的皮损颜色从浅褐色到蓝色，甚至是绿黑色。为制定最佳治疗指南，我们评估了根据颜色分类的此类皮损消除色素沉着所需的调Q红宝石激光治疗次数。在6年的时间里，我们评估了151例接受调Q红宝石激光低能量水平（波长694.3nm；脉冲持续时间28×10⁻⁹s；能量密度5J/cm²；光斑大小6.5mm）治疗的日本太田痣患者，每2个月治疗一次。每个皮损根据颜色分为褐色（n = 22）、褐紫色（n = 42）、紫蓝色（n = 81）和蓝绿色（n = 6）。在接受三次激光治疗的所有患者中，22个主要为褐色的皮损均获得了极佳（100 - 95%）或良好（95 - 75%）的美容效果。在42个褐紫色皮损中，29个获得良好或极佳效果的患者中有25个在接受四次治疗后达到；13个效果较差的患者接受了一至三次治疗。在81个紫蓝色皮损中，65个获得良好或极佳效果的患者中有54个在接受四次治疗后达到，65个中有64个在接受五次治疗后达到，而所有16个效果较差的患者仅接受了一至三次治疗。然而，在6个蓝绿色皮损中，需要六次或更多次治疗才能获得同样良好的效果。治疗结束时，治疗区域几乎没有瘢痕形成，其质地与周围正常皮肤相似。我们已经证实，使用低能量水平的调Q红宝石激光可以消除太田痣的色素沉着。虽然在1年内可以获得理想的改善，但治疗次数似乎取决于皮损的主要颜色。
