免疫刺激细菌DNA序列可激活树突状细胞，并促进CD8 + T细胞的致敏和分化。
Immunostimulatory bacterial DNA sequences activate dendritic cells and promote priming and differentiation of CD8+ T cells.
作者信息
Tascon R E, Ragno S, Lowrie D B, Colston M J
机构信息
Mycobacterial Division, National Institute for Medical Research, London, UK.
出版信息
Immunology. 2000 Jan;99(1):1-7. doi: 10.1046/j.1365-2567.2000.00941.x.
Abstract
CD8+ T lymphocytes producing high levels of interferon-gamma (IFN-gamma) and expressing antigen specific cytotoxic activity are effectively induced after plasmid DNA vaccination and mediate protection against several intracellular micro-organisms. Recent evidence suggests that the priming of CD8+ T-cell responses following DNA injection involves antigen presentation mediated by dendritic cells. Here, we show that bacterial DNA and synthetic oligonucleotides containing dinucleotide (CpG) motifs activate cytokine expression in dendritic cells and modulate in vivo CD8+ T-cell priming and differentiation.
摘要
质粒DNA疫苗接种后可有效诱导产生高水平干扰素-γ（IFN-γ）并表达抗原特异性细胞毒性活性的CD8+ T淋巴细胞，介导针对多种细胞内微生物的保护作用。最近的证据表明，DNA注射后CD8+ T细胞反应的启动涉及树突状细胞介导的抗原呈递。在此，我们表明含有二核苷酸（CpG）基序的细菌DNA和合成寡核苷酸可激活树突状细胞中的细胞因子表达，并调节体内CD8+ T细胞的启动和分化。
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