Derebery M J
House Ear Clinic and House Ear Institute, Los Angeles, CA 90057, USA.
Otolaryngol Head Neck Surg. 2000 Feb;122(2):174-82. doi: 10.1016/S0194-5998(00)70235-X.
The effect of allergy immunotherapy and elimination of suspected food allergens was evaluated in patients with Meniere's disease. A total of 137 patients with Meniere's disease for whom allergy treatment had been recommended were identified and were mailed and returned a symptoms questionnaire. One hundred thirteen had received allergy treatment; 24 did not have treatment and served as a control group. Information regarding history, signs and symptoms, allergy test results, and audiologic data were obtained by chart review. The 113 patients treated with desensitization and diet showed a significant improvement from pretreatment to posttreatment in both allergy and Meniere's symptoms. Ratings of frequency, severity, and interference with everyday activities of their Meniere's symptoms also appeared better after allergy treatment than ratings from the control group of untreated patients. Vertigo control results, by use of the American Academy of Otolaryngology-Head and Neck Surgery classification, categorized 47.9% as class A or B. Hearing was stable or improved in 61.4%. Patients with Meniere's disease can show improvement in their symptoms of tinnitus and vertigo when receiving specific allergy therapy. The inner ear may be the target, directly or indirectly, of an allergic reaction.
对梅尼埃病患者进行了变应性免疫疗法及去除可疑食物变应原的效果评估。共识别出137例被建议进行变应性治疗的梅尼埃病患者,并向其邮寄了症状调查问卷且问卷得到了回复。113例接受了变应性治疗;24例未接受治疗作为对照组。通过查阅病历获取了有关病史、体征和症状、变应性检测结果及听力学数据的信息。113例接受脱敏和饮食治疗的患者在变应性症状和梅尼埃病症状方面从治疗前到治疗后均有显著改善。变应性治疗后,其梅尼埃病症状的频率、严重程度及对日常活动的干扰评分也比未治疗的对照组患者的评分更好。根据美国耳鼻咽喉头颈外科学会的分类,眩晕控制结果将47.9%的患者归类为A类或B类。61.4%的患者听力稳定或改善。梅尼埃病患者接受特异性变应性治疗时,耳鸣和眩晕症状可能会有所改善。内耳可能直接或间接成为变应性反应的靶点。