利用功能磁共振成像评估听觉皮层激活情况。

Assessment of auditory cortex activation with functional magnetic resonance imaging.

作者信息

Ulualp S O, Biswal B B, Yetkin F Z, Kidder T M

机构信息

Department of Otolaryngology and Communication Sciences and Biophysics Research Institute, Medical College of Wisconsin, Milwaukee 53226-3522, USA.

出版信息

Otolaryngol Head Neck Surg. 2000 Feb;122(2):241-5. doi: 10.1016/S0194-5998(00)70247-6.

DOI:10.1016/S0194-5998(00)70247-6

PMID:10652398

Abstract

OBJECTIVE

The goal was to assess auditory cortex activation evoked by pure-tone stimulus with functional MRI.

METHODS

Five healthy children, aged 7 to 10 years, were studied. Hearing evaluation was performed by pure-tone audiometry in a sound-treated room and in the MRI scanner with the scanner noise in the background. Subjects were asked to listen to pure tones (500, 1000, 2000, and 4000 Hz) at thresholds determined in the MRI scanner. Functional image processing was performed with a cross-correlation technique with a correlation coefficient of 0.5 (P < 0.0001). Auditory cortex activation was assessed by observing activated pixels in functional images.

RESULTS

Functional images of auditory cortex activation were obtained in 3 children. All children showed activation in Heschl's gyrus, middle temporal gyrus, superior temporal gyrus, and planum temporale. The number of activated pixels in auditory cortexes ranged from 4 to 33.

CONCLUSIONS

Functional images of auditory cortex activation evoked by pure-tone stimuli are obtained in healthy children with the functional MRI technique.

摘要

目的

本研究旨在通过功能磁共振成像（fMRI）评估纯音刺激诱发的听觉皮层激活情况。

方法

对5名7至10岁的健康儿童进行研究。在隔音室内通过纯音听力计进行听力评估，并在背景有扫描仪噪声的磁共振成像扫描仪中进行。要求受试者在磁共振成像扫描仪中确定的阈值下聆听纯音（500、1000、2000和4000赫兹）。采用互相关技术进行功能图像处理，相关系数为0.5（P<0.0001）。通过观察功能图像中激活的像素来评估听觉皮层的激活情况。