Yetkin F Zerrin, Roland Peter S, Mendelsohn Dianne B, Purdy Phillip D
Department of Radiology, University of Texas Southwestern Medical Center at Dallas, 75390-8896, USA.
Laryngoscope. 2004 Jan;114(1):96-101. doi: 10.1097/00005537-200401000-00017.
Functional magnetic resonance imaging (fMRI) has been used to investigate activation of the auditory cortex; however, assessment of activation in the subcortical auditory pathway has been challenging. The aim of this study was to examine neural correlates of cortical and subcortical auditory activation evoked by pure-tone stimulus using silent fMRI.
Prospective analysis.
Seventeen normal-hearing volunteers (7 male, 10 female; age range, 14-37 yrs) underwent silent fMRI. An audiometer was used to deliver pure tones of 1000 Hz to the left ear. Pure tones were presented at hearing thresholds determined in the scanner. Brain regions showing increased activation during pure-tone stimulus presentation were mapped and auditory activations exceeding P <.001 were included in the analysis.
Pure-tone stimuli evoked bilateral activation in cortical regions of the transverse and superior temporal gyri and the planum temporale. Activation in subcortical structures included the medial geniculate body, inferior colliculus, lateral lemniscus, superior olivary complex, and cochlear nucleus.
Silent functional magnetic resonance imaging findings documented the feasibility of detecting activation elicited by pure tone along the cortical and subcortical auditory pathway. The use of this technique in the assessment of disorders with auditory dysfunction merits further investigation.
功能磁共振成像（fMRI）已被用于研究听觉皮层的激活；然而，评估皮层下听觉通路的激活一直具有挑战性。本研究的目的是使用静息态fMRI检查纯音刺激诱发的皮层和皮层下听觉激活的神经相关性。
前瞻性分析。
17名听力正常的志愿者（7名男性，10名女性；年龄范围14 - 37岁）接受静息态fMRI检查。使用听力计向左耳输送1000Hz的纯音。纯音在扫描仪中测定的听力阈值下呈现。绘制纯音刺激呈现期间显示激活增加的脑区，并将超过P<0.001的听觉激活纳入分析。
纯音刺激在颞横回、颞上回和颞平面的皮层区域诱发双侧激活。皮层下结构的激活包括内侧膝状体、下丘、外侧丘系、上橄榄复合体和蜗神经核。
静息态功能磁共振成像结果证明了检测纯音沿皮层和皮层下听觉通路诱发激活的可行性。该技术在评估听觉功能障碍疾病中的应用值得进一步研究。
