Arisawa K, Soda M, Endo S, Kurokawa K, Katamine S, Shimokawa I, Koba T, Takahashi T, Saito H, Doi H, Shirahama S
Department of Preventive Medicine and Health Promotion, Nagasaki University School of Medicine, Japan.
Int J Cancer. 2000 Feb 1;85(3):319-24. doi: 10.1002/(sici)1097-0215(20000201)85:3<319::aid-ijc4>3.0.co;2-b.
The incidence of adult T-cell leukemia/lymphoma (ATL) and its impact on that of total non-Hodgkin lymphoma (NHL) were evaluated in Nagasaki, an area in southwestern Japan where human T-cell lymphotropic virus type I (HTLV-I) is endemic. The first study area comprised 4 towns located on the K Islands, which had a population of 26,870 in 1990. The overall HTLV-I seroprevalence estimated from the serologic survey of 18,485 subjects was 16.2%. By using the data from the Nagasaki Prefectural Cancer Registry (NPCR) and reviewing clinical and laboratory information, we identified 40 cases of ATL and 35 cases of other NHL diagnosed between 1985 and 1995. The crude annual incidence of ATL among 100,000 HTLV-I carriers aged 30 or older was estimated at 137.7 for men and 57.4 for women, with a significant sex difference after adjustment for age (rate ratio = 2.50, 95% confidence interval 1.32-4.73). The cumulative risk from 30 to 79 years of age was estimated at approximately 6.6% for men and 2.1% for women. Among the entire population, ATL accounted for 51 to 59% of the total NHL incidence, showing the strong impact of HTLV-I infection. The second study area comprised the whole of Nagasaki Prefecture (total population in 1990 = 1.56 million). Between 1985 and 1995, 989 cases of ATL and 1,745 cases of other NHL were registered in the NPCR. The world age-standardized annual incidence rate of ATL per 100,000 persons aged 30 or older was estimated at 10.5 for men and 6.0 for women, which accounted for approximately 37 to 41% of the total NHL incidence.
在日本西南部人类嗜T淋巴细胞病毒I型（HTLV-I）流行的长崎地区，评估了成人T细胞白血病/淋巴瘤（ATL）的发病率及其对非霍奇金淋巴瘤（NHL）总发病率的影响。第一个研究区域包括K岛的4个城镇，1990年人口为26,870人。根据对18,485名受试者的血清学调查估计，HTLV-I总体血清阳性率为16.2%。通过使用长崎县癌症登记处（NPCR）的数据并审查临床和实验室信息，我们确定了1985年至1995年间诊断出的40例ATL和35例其他NHL。30岁及以上的100,000名HTLV-I携带者中，ATL的粗年发病率估计男性为137.7，女性为57.4，年龄调整后存在显著性别差异（率比=2.50，95%置信区间1.32 - 4.73）。30至79岁的累积风险估计男性约为6.6%，女性为2.1%。在整个人口中，ATL占NHL总发病率的51%至59%，显示出HTLV-I感染的强烈影响。第二个研究区域包括整个长崎县（1990年总人口=156万）。1985年至1995年间，NPCR登记了989例ATL和1,745例其他NHL。30岁及以上人群中，ATL的世界年龄标准化年发病率估计男性为每10万人10.5例，女性为6.0例，约占NHL总发病率的37%至41%。
