Iwanaga M, Fujiwara S, Oikawa O, Sugiura M, Imai S, Osato T, Mikuni C, Maekawa I, Miyazaki T
Department of Virology, Cancer Institute, Hokkaido University School of Medicine, Sapporo, Japan.
In Vivo. 1995 Jan-Feb;9(1):49-53.
Family members of patients with adult T-cell leukemia (ATL) in non-ATL-endemic Hokkaido, the northernmost part of Japan, were assessed for the prevalence of HTLV-I infection. Immunofluorescence assay showed that 53 out of 133 (39.8%) healthy family members of 23 ATL patients were positive for antibodies to HTLV-I. When general inhabitants in Hokkaido were examined, 3 out of 18 (16.7%) family members of 5 seropositive healthy persons had HTLV-I antibodies. The overall seropositivity in Hokkaido was 0.7%. Of 26 family members of 6 patients with non-T-cell leukemia seroconverted by blood transfusion, none (0%) was seropositive.
在日本最北部非成人T细胞白血病（ATL）流行地区北海道，对ATL患者的家庭成员进行了HTLV-I感染率评估。免疫荧光分析显示，23例ATL患者的133名健康家庭成员中，有53人（39.8%）HTLV-I抗体呈阳性。在对北海道普通居民进行检查时，5名血清反应阳性健康人的18名家庭成员中有3人（16.7%）有HTLV-I抗体。北海道的总体血清阳性率为0.7%。6例因输血导致血清转化的非T细胞白血病患者的26名家庭成员中，无一例（0%）血清反应阳性。
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