调节趋化因子：来自病毒的更多经验教训。

Modulating chemokines: more lessons from viruses.

作者信息

Lalani A S, Barrett J W, McFadden G

机构信息

Howard Hughes Medical Institute, Dept of Microbiology and Immunology, University of California San Francisco, 94143-0414, USA.

出版信息

Immunol Today. 2000 Feb;21(2):100-6. doi: 10.1016/s0167-5699(99)01556-x.

DOI:10.1016/s0167-5699(99)01556-x

PMID:10652469

Abstract

Chemokines are crucial effector molecules involved in orchestrating the host inflammatory response against invading pathogens. Viruses have devised several strategies for exploiting or neutralizing chemokines or their receptors to further their own propagation or elude host defenses. Insight into strategies used by viruses to modulate chemokines might help generate novel approaches for treating viral diseases and chemokine-mediated inflammatory disorders.

摘要

趋化因子是参与协调宿主针对入侵病原体的炎症反应的关键效应分子。病毒已经设计出多种策略来利用或中和趋化因子或其受体，以促进自身繁殖或逃避宿主防御。深入了解病毒用于调节趋化因子的策略可能有助于产生治疗病毒性疾病和趋化因子介导的炎症性疾病的新方法。