Mantovani Alberto, Bonecchi Raffaella, Locati Massimo
Istituto Clinico Humanitas, Via Manzoni 56, 20089 Rozzano, Milan, Italy and Istituto di Patologia Generale, Università degli Studi di Milano, Via Luigi Mangiagalli 31, 20133 Milan.
Nat Rev Immunol. 2006 Dec;6(12):907-18. doi: 10.1038/nri1964.
A set of chemokine receptors are structurally unable to elicit migration or conventional signalling responses after ligand engagement. These 'silent' (non-signalling) chemokine receptors regulate inflammatory and immune reactions in different ways, including by acting as decoys and scavengers. Chemokine decoy receptors recognize distinct and complementary sets of ligands and are strategically expressed in different cellular contexts. Importantly, viruses and parasites have evolved multiple strategies to elude chemokines, including the expression of decoy receptors. So, decoy receptors for chemokines represent a general strategy to tune, shape and temper innate and adaptive immunity.
一组趋化因子受体在配体结合后在结构上无法引发迁移或传统的信号反应。这些“沉默”（无信号）趋化因子受体以不同方式调节炎症和免疫反应，包括充当诱饵和清除剂。趋化因子诱饵受体识别不同且互补的配体组，并在不同细胞环境中策略性地表达。重要的是，病毒和寄生虫已经进化出多种逃避趋化因子的策略，包括表达诱饵受体。因此，趋化因子的诱饵受体代表了一种调节、塑造和调节先天免疫和适应性免疫的通用策略。
