Hannun Y A, Luberto C
Dept of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston 29495, USA.
Trends Cell Biol. 2000 Feb;10(2):73-80. doi: 10.1016/s0962-8924(99)01694-3.
Several extracellular agents and stress stimuli, such as tumour necrosis factor alpha, chemotherapeutic agents and heat, cause ceramide accumulation. They do this by regulating enzymes involved in its metabolism. Ceramide modulates a number of biochemical and cellular responses to stress, including apoptosis, cell-cycle arrest and cell senescence.
几种细胞外因子和应激刺激，如肿瘤坏死因子α、化疗药物和热，会导致神经酰胺积累。它们通过调节参与其代谢的酶来实现这一点。神经酰胺调节许多对压力的生化和细胞反应，包括细胞凋亡、细胞周期停滞和细胞衰老。
