RAP，RAP，开门！酵母中RAP1的新情况。

RAP, RAP, open up! New wrinkles for RAP1 in yeast.

作者信息

Morse R H

机构信息

Molecular Genetics Program, Wadsworth Center, New York State Dept of Health, and State University of New York School of Public Health, Albany, NY 12201-2002, USA.

出版信息

Trends Genet. 2000 Feb;16(2):51-3. doi: 10.1016/s0168-9525(99)01936-8.

DOI:10.1016/s0168-9525(99)01936-8

PMID:10652526

Abstract

RAP1 (repressor/activator protein 1) from budding yeast is well known for its involvement in gene activation and repression, telomere structure and function, and replication. Recent studies have examined additional roles for RAP1 in heterochromatin boundary-element formation, creation of hotspots for meiotic recombination, and chromatin opening. These studies provide new insight into the ability of this abundant DNA-binding protein to participate in a diverse array of functions taking place in a chromatin environment.

摘要

来自芽殖酵母的RAP1（阻遏物/激活蛋白1）因其参与基因激活与抑制、端粒结构与功能以及复制而广为人知。最近的研究探讨了RAP1在异染色质边界元件形成、减数分裂重组热点的产生以及染色质开放方面的其他作用。这些研究为这种丰富的DNA结合蛋白参与染色质环境中多种功能的能力提供了新的见解。