Primakoff P, Myles D G
Department of Cell Biology and Anatomy, School of Medicine, University of California, Davis, CA 95616, USA.
Trends Genet. 2000 Feb;16(2):83-7. doi: 10.1016/s0168-9525(99)01926-5.
An ADAM is a transmembrane protein that contains a disintegrin and metalloprotease domain and, therefore, it potentially has both cell adhesion and protease activities. Currently, the ADAM gene family has 29 members, although the function of most ADAM gene products is unknown. We discuss the ADAM gene products with known functions that act in a highly diverse set of biological processes, including fertilization, neurogenesis, myogenesis, embryonic TGF-alpha release and the inflammatory response.
解整合素金属蛋白酶（ADAM）是一种跨膜蛋白，其包含一个解整合素和金属蛋白酶结构域，因此它可能同时具有细胞黏附活性和蛋白酶活性。目前，ADAM基因家族有29个成员，不过大多数ADAM基因产物的功能尚不清楚。我们将讨论具有已知功能的ADAM基因产物，这些产物参与了一系列高度多样的生物学过程，包括受精、神经发生、肌发生、胚胎转化生长因子-α释放以及炎症反应。
