Gershony G, Jensen T
John Muir Medical Center, Walnut Creek, California, USA.
Herz. 1999 Dec;24(8):614-9. doi: 10.1007/BF03044485.
Purpose of this paper is to investigate the hemostatic capabilities of a novel vascular sealing device consisting of a balloon catheter and procoagulant. Vascular sheaths were placed percutaneously in the femoral arteries of dogs. The sealing device was evaluated using the balloon catheter alone in 6 femoral arteries and with the addition of a procoagulant in 21 femoral arteries. The balloon catheter alone was successfully deployed in 6 of 6 femoral arteries achieving immediate hemostasis. In a second study in which the procoagulant was delivered following balloon placement, the sealing device was successfully deployed and hemostasis was achieved in 20 of 21 attempts (95%) despite removal of the balloon catheter. In a subset of fully anticoagulated animals, hemostasis was achieved in the sealing device-treated arteries at 6.5 +/- 3.4 minutes but in none of the controls (p < 0.001). This novel vascular sealing device successfully achieves rapid hemostasis in normal and anticoagulated dogs following percutaneous vascular procedures.
本文的目的是研究一种由球囊导管和促凝剂组成的新型血管封闭装置的止血能力。经皮在犬股动脉中放置血管鞘。在6条股动脉中单独使用球囊导管，在21条股动脉中添加促凝剂来评估该封闭装置。单独使用球囊导管时，6条股动脉中有6条成功部署，实现了即时止血。在第二项研究中，在放置球囊后注入促凝剂，尽管移除了球囊导管，但在21次尝试中有20次（95%）成功部署了封闭装置并实现了止血。在一组完全抗凝的动物中，经封闭装置治疗的动脉在6.5±3.4分钟时实现了止血，但对照组均未实现止血（p<0.001）。这种新型血管封闭装置在经皮血管手术后能在正常和抗凝犬中成功实现快速止血。
