一种肠溶包衣阿司匹林制剂的评估。

Evaluation of an enteric coated aspirin preparation.

作者信息

Day R O, Paull P D, Champion G D, Graham G G

出版信息

Aust N Z J Med. 1976 Feb;6(1):45-50. doi: 10.1111/j.1445-5994.1976.tb03290.x.

DOI:10.1111/j.1445-5994.1976.tb03290.x

Abstract

The bioavailability and gastrointestinal site of release of enteric coated aspirin tablets ("Rhusal", G.P. Laboratories) were investigated following dosage with single tablets. A delay of one to more than eight hours was observed between dosage and the appearance of salicylate in plasma or saliva. This delay was decreased by pretreatment with metoclopramide. No aspirin or salicylate was detected in gastric aspirates. The mean urinary recovery of salicylate was equivalent to 92% of the administered dose. All these tests were consistent with the designed function of the enteric coating. The time course of concentrations of salicylate in saliva rather than in plasma was confirmed as a useful technique for the evaluation of different formulations of aspirin. The acceleration of gastric emptying by metoclopramide is a useful technique for the evaluation of enteric coated tablets.

摘要

对肠溶阿司匹林片（“Rhusal”，G.P.实验室出品）单剂量给药后的生物利用度及胃肠道释放部位进行了研究。给药后与血浆或唾液中水杨酸盐出现之间观察到延迟1至8个多小时。甲氧氯普胺预处理可减少这种延迟。胃吸出物中未检测到阿司匹林或水杨酸盐。水杨酸盐的平均尿回收率相当于给药剂量的92%。所有这些试验均与肠溶包衣的设计功能相符。唾液而非血浆中水杨酸盐浓度的时间进程被确认为评估不同阿司匹林制剂的有用技术。甲氧氯普胺加速胃排空是评估肠溶片剂的有用技术。