Nap R C, Breen D J, Lam T J, Peters I O, Willemsen A, De Bruyne J J
Vakgroep Geneeskunde van Gezelschapsdieren, Universiteit Utrecht.
Tijdschr Diergeneeskd. 1993 Jul 15;118(13):439-42.
Administration of acetylsalicylic acid (aspirin) in the dog may cause gastric mucosal damage. Enteric-coated tablets protect the canine stomach during oral aspirin medication. A therapeutic plasma salicylate concentration can be attained using enteric-coated aspirin tablets at a dosage of 25 mg/kg TID. In a series 4 of experiments using adult beagle and large mixed breed dogs and two types enteric-coated tablets, the influence of food intake on the plasma salicylate concentration was studied. Tablets were administered with 8h intervals and food intake was either once daily or three time daily with 8h intervals. Plasma salicylate concentrations were also studied during fasting. It is concluded that, when using enteric-coated tablets, the plasma salicylate concentration in the dog after oral medication is strongly influenced by the aspirin dosage, the tablet type and the feeding pattern. Large enteric-coated tablets may accumulate in the stomach over several days and are not suitable for use in the dog. The gastric accumulation is caused by the enteric-coating of the large tablets and not by the aspirin medication.
给犬服用乙酰水杨酸（阿司匹林）可能会导致胃黏膜损伤。肠溶衣片在口服阿司匹林药物期间可保护犬的胃部。使用剂量为25mg/kg、每日三次的肠溶衣阿司匹林片可达到治疗性血浆水杨酸浓度。在一系列使用成年比格犬和大型混种犬以及两种类型肠溶衣片的4项实验中，研究了食物摄入对血浆水杨酸浓度的影响。片剂每隔8小时给药一次，食物摄入要么每天一次，要么每隔8小时每天三次。还在禁食期间研究了血浆水杨酸浓度。得出的结论是，使用肠溶衣片时，犬口服药物后血浆水杨酸浓度受阿司匹林剂量、片剂类型和喂养方式的强烈影响。大型肠溶衣片可能会在胃中累积数天，不适合用于犬。胃内累积是由大片剂的肠溶衣引起的，而非阿司匹林药物。
