Dürr H R, Lienemann A, Nerlich A, Stumpenhausen B, Refior H J
Orthopädische Klinik und Poliklinik, Ludwig-Maximilians-Universität München, Klinikum Grosshadern, Munich, Germany.
Arch Orthop Trauma Surg. 2000;120(1-2):42-7. doi: 10.1007/pl00021214.
Chondromyxoid fibroma is a benign, although potentially aggressive tumor, with a cartilage-like matrix, accounting for approximately 1% of all bone tumors. It usually affects the metaphyseal region of long bones of patients in their first or second decade of life. An additional peak of incidence has been observed between 50 and 70 years of age. Three cases are presented here: 10-, 13-, and 52-year-old patients, with lesions in the proximal tibia, the proximal humerus, and the proximal femur, respectively. The literature is reviewed in terms of clinical behavior, diagnostic procedures, prognostic factors, treatment, and outcome. Preferred treatment is complete local excision with tumor-free margins. Intralesional curettage with or without local adjuvants shows a local recurrence rate of approximately 25%. Radiation therapy may be useful in nonresectable cases but bears the well documented risk of radiation-induced malignancies.
软骨黏液样纤维瘤是一种良性肿瘤，尽管具有潜在侵袭性，其基质类似软骨，约占所有骨肿瘤的1%。它通常影响10到20岁患者长骨的干骺端区域。在50至70岁之间观察到另一个发病高峰。本文介绍3例病例：分别为10岁、13岁和52岁的患者，病变部位分别在胫骨近端、肱骨近端和股骨近端。本文从临床行为、诊断方法、预后因素、治疗及结果等方面对文献进行了综述。首选治疗方法是进行切缘无肿瘤的完整局部切除。病灶内刮除术无论是否使用局部辅助剂，局部复发率约为25%。放射治疗在不可切除的病例中可能有用，但存在有充分记录的辐射诱发恶性肿瘤的风险。
