Johnson G F
Aust N Z J Psychiatry. 1976 Mar;10(1):33-8. doi: 10.3109/00048677609159483.
One of the most alarming and potentially serious complications of Lithium Carbonate therapy is the emergence of central nervous system toxicity. This paper discusses the clinical changes that may occur with illustrative case histories. The role that such factors as serum Lithium levels, sodium balance, organic brain damage, clinical typology, concurrent physical illness and drug interaction play in the genesis of this disorder is discussed. Permanent neurological damage following Lithium poisoning is discussed and guidelines for appropriate use and monitoring of Lithium in psychiatric disorders is outlined.
碳酸锂治疗最令人担忧且可能严重的并发症之一是中枢神经系统毒性的出现。本文通过实例病史讨论了可能发生的临床变化。探讨了血清锂水平、钠平衡、器质性脑损伤、临床类型、并发躯体疾病和药物相互作用等因素在该病症发生过程中所起的作用。讨论了锂中毒后的永久性神经损伤，并概述了在精神疾病中合理使用和监测锂的指导原则。
