Nagaraja D, Taly A B, Sahu R N, Channabasavanna S M, Narayanan H S
Clin Neurol Neurosurg. 1987;89(1):31-4. doi: 10.1016/s0303-8467(87)80072-0.
Lithium intoxication is well known to produce acute and chronic symptoms but development of permanent neurological deficit is a rarity. Six cases of manic depressive psychosis who developed neurological sequelae following treatment with lithium carbonate are described. There were multiple lesions in the central nervous system. However, the main brunt was borne by cerebellum. The serum lithium levels of five patients were within therapeutic range. The value of identifying the precipitating factors, early diagnosis and prompt intervention in the prevention of persistent neurological dysfunction is emphasized.
锂中毒会引发急性和慢性症状，这是众所周知的，但永久性神经功能缺损的情况却很罕见。本文描述了6例因碳酸锂治疗而出现神经后遗症的躁狂抑郁症患者。中枢神经系统存在多处病变。然而，主要受损部位是小脑。5例患者的血清锂水平在治疗范围内。强调了识别诱发因素、早期诊断和及时干预对预防持续性神经功能障碍的价值。
