Laureys S, Salmon E, Garraux G, Peigneux P, Lemaire C, Degueldre C, Franck G
Cyclotron Research Center, and Department of Neurology, University of Liège, Belgium.
J Neurol. 1999 Dec;246(12):1151-8. doi: 10.1007/s004150050534.
Fluorodopa (FDOPA) and fluorodeoxyglucose (FDG) PET was performed in six patients in early stages of corticobasal degeneration (CBD) and compared to Parkinson's disease (PD) patients with a similar degree of bradykinesia and rigidity and to healthy controls. Statistical parametric mapping analysis comparing CBD to controls showed metabolic decrease in premotor, primary motor, supplementary motor, primary sensory, prefrontal, and parietal associative cortices, and in caudate and thalamus contralateral to the side of clinical signs. Except for the prefrontal regions a similar metabolic pattern was observed when CBD was compared to PD. Putamen FDOPA uptake was decreased in both CBD and PD. Caudate FDOPA uptake in CBD patients was decreased contralateral to clinical signs when compared to controls, but was higher than in PD. In early stages of CBD, FDOPA and FDG PET patterns differed from those observed in PD. In CBD the asymmetry in FDOPA uptake was less pronounced than that of clinical signs or metabolic impairment.
对6例皮质基底节变性（CBD）早期患者进行了氟多巴（FDOPA）和氟脱氧葡萄糖（FDG）正电子发射断层显像（PET）检查，并与具有相似程度运动迟缓及强直的帕金森病（PD）患者以及健康对照者进行比较。将CBD患者与对照者进行比较的统计参数映射分析显示，运动前区、初级运动区、辅助运动区、初级感觉区、前额叶和顶叶联合皮质以及与临床体征同侧的尾状核和丘脑代谢降低。当将CBD患者与PD患者进行比较时，除前额叶区域外，观察到了相似的代谢模式。壳核FDOPA摄取在CBD和PD患者中均降低。与对照者相比，CBD患者临床体征对侧的尾状核FDOPA摄取降低，但高于PD患者。在CBD早期，FDOPA和FDG PET模式与PD患者中观察到的模式不同。在CBD中，FDOPA摄取的不对称性不如临床体征或代谢损害明显。
