海洋apiside，一种从海洋海绵菲律宾海洋apia中提取的抗真菌双-α，ω-氨基醇糖苷。
Oceanapiside, an antifungal bis-alpha,omega-amino alcohol glycoside from the marine sponge Oceanapia phillipensis.
作者信息
Nicholas G M, Hong T W, Molinski T F, Lerch M L, Cancilla M T, Lebrilla C B
机构信息
Department of Chemistry, University of California, Davis 95616, USA.
出版信息
J Nat Prod. 1999 Dec;62(12):1678-81. doi: 10.1021/np990190v.
PMID:10654417
Abstract
The structure of oceanapiside, an antifungal alpha, omega-bis-aminohydroxylipid glycoside from the temperate marine sponge Oceanapia sp., was elucidated by a combination of 2D NMR, chemical degradation/correlation, and MALDI MS-MS spectrometry. Oceanapiside exhibits antifungal activity against Candida glabrata at 10 micrograms/mL (MIC).
摘要
海洋apiside是一种从温带海洋海绵Oceanapia sp.中提取的抗真菌α,ω-双氨基羟基脂质糖苷，其结构通过二维核磁共振、化学降解/关联和基质辅助激光解吸电离串联质谱法相结合的方法得以阐明。海洋apiside在浓度为10微克/毫升（最低抑菌浓度）时对光滑念珠菌具有抗真菌活性。
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