海洋海绵属次级代谢产物：化学与生物活性。

College of Materials Science and Engineering, Central South University of Forestry and Technology, Changsha 410004, China.

Mar Drugs. 2022 Feb 16;20(2):144. doi: 10.3390/md20020144.

In this review, we summarized the distribution of the chemically investigated sponges, including the isolation and biological activities of their secondary metabolites, covering the literature from the first report in 1989 to July 2019. There have been 110 compounds reported during this period, including 59 alkaloids, 33 lipids, 14 sterols and 4 miscellaneous compounds. Besides their unique structures, they exhibited promising bioactivities ranging from insecticidal to antibacterial. Their complex structural characteristics and diverse biological properties have attracted a great deal of attention from chemists and pharmaceuticals seeking to perform their applications in the treatment of disease.

在这篇综述中，我们总结了已研究过的海绵的分布情况，包括它们的次生代谢产物的分离和生物活性，涵盖了从 1989 年第一篇报道到 2019 年 7 月的文献。在此期间，已经有 110 种化合物被报道，包括 59 种生物碱、33 种脂类、14 种甾醇和 4 种杂类化合物。除了它们独特的结构外，它们还表现出了从杀虫到抗菌等广泛的生物活性。它们复杂的结构特征和多样的生物性质引起了化学家们和制药公司的极大关注，他们希望将这些化合物应用于疾病的治疗。