Mullins M E, Brands C L, Daya M R
Oregon Poison Center, Department of Emergency Medicine, Oregon Health Sciences Center, Portland, Oregon, USA.
Pediatrics. 2000 Feb;105(2):402-4. doi: 10.1542/peds.105.2.402.
To determine whether routine follow-up coagulation studies are useful in children with accidental exposures to rodenticides containing superwarfarin compounds.
Retrospective review of poison center charts involving pediatric superwarfarin exposures occurring in two 2-year periods.
An American Association of Poison Control Centers-certified regional poison control center with an annual call volume of 55 000 calls per year from a 2-state area with a combined population of 4 million people.
Prothrombin times and/or international normalized ratios and reported clinical signs of excessive anticoagulation after exposure.
Of 542 children in 4 years of data collection, follow-up prothrombin times and/or international normalized ratios measurements did not detect any significant coagulation abnormalities. No child developed bleeding complications. No child required or received antidotal treatment with vitamin K.
Normal preschool-aged children with unintentional acute exposures to superwarfarin rodenticides do not require any routine follow-up laboratory studies and do not require any medical intervention.
确定常规随访凝血检查对意外接触含超级华法林化合物灭鼠剂的儿童是否有用。
回顾性分析两个为期2年的时间段内儿科超级华法林暴露的中毒控制中心图表。
一家获得美国毒物控制中心协会认证的地区毒物控制中心，每年接到来自两个州、总人口400万地区的55000个电话。
凝血酶原时间和/或国际标准化比值以及暴露后报告的过度抗凝临床体征。
在4年的数据收集期内，对542名儿童进行随访，凝血酶原时间和/或国际标准化比值测量未发现任何显著的凝血异常。没有儿童出现出血并发症。没有儿童需要或接受维生素K解毒治疗。
意外急性接触超级华法林灭鼠剂的正常学龄前儿童不需要任何常规随访实验室检查，也不需要任何医疗干预。
