Ahtiluoto S, Mannonen L, Paetau A, Vaheri A, Koskiniemi M, Rautiainen P, Muttilainen M
Pediatrics. 2000 Feb;105(2):431-3. doi: 10.1542/peds.105.2.431.
A 23-month-old girl died after 2 days' illness with rash, fever, and convulsions. Neuropathologic findings were consistent with viral hemorrhagic encephalitis in pontine tegmentum and medial thalamic areas. Human herpesvirus 6 (HHV-6) DNA was detected in pontine nuclei by in situ hybridization. In addition, polymerase chain reaction for HHV-6 of serum and paraffin-embedded pontine tissue was positive, and serology indicated an acute primary infection. This is the first case showing HHV-6 DNA in the brain cells of an immunocompetent patient with acute encephalitis.
一名23个月大的女童在出现皮疹、发热和惊厥症状2天后死亡。神经病理学检查结果显示，脑桥被盖部和丘脑内侧区域符合病毒性出血性脑炎表现。通过原位杂交在脑桥核中检测到人类疱疹病毒6型（HHV-6）DNA。此外，血清和石蜡包埋的脑桥组织的HHV-6聚合酶链反应呈阳性，血清学检查表明为急性原发性感染。这是首例在具有免疫能力的急性脑炎患者脑细胞中发现HHV-6 DNA的病例。
