疑似病毒起源的中枢神经系统感染：来自芬兰的一项合作研究。
Infections of the central nervous system of suspected viral origin: a collaborative study from Finland.
作者信息
Koskiniemi M, Rantalaiho T, Piiparinen H, von Bonsdorff C H, Färkkilä M, Järvinen A, Kinnunen E, Koskiniemi S, Mannonen L, Muttilainen M, Linnavuori K, Porras J, Puolakkainen M, Räihä K, Salonen E M, Ukkonen P, Vaheri A, Valtonen V
机构信息
The Haartman Institute, Department of Virology, University of Helsinki, Finland.
出版信息
J Neurovirol. 2001 Oct;7(5):400-8. doi: 10.1080/135502801753170255.
We studied 3231 patients with acute central nervous system (CNS) symptoms of suspected viral origin to elucidate the current etiologic spectrum. In 46% of the cases, a viral finding was observed. Varicella-zoster virus (VZV) was the main agent associated with encephalitis, as well as meningitis and myelitis. VZV comprised 29% of all confirmed or probable etiologic agents. Herpes simplex virus (HSV) and enteroviruses accounted 11% each, and influenza A virus 7%. VZV seems to have achieved a major role in viral infections of CNS. In encephalitis in our population, VZV is clearly more commonly associated with these neurological diseases than HSV. The increase in VZV findings may in part be a pseudophenomenon due to improved diagnostic methods, however, a true increase may have occurred and the pathogenetic mechanisms behind this should be elucidated.
我们研究了3231例有疑似病毒起源的急性中枢神经系统（CNS）症状的患者，以阐明当前的病因谱。在46%的病例中，观察到病毒感染迹象。水痘带状疱疹病毒（VZV）是与脑炎、脑膜炎和脊髓炎相关的主要病原体。VZV占所有确诊或可能的病原体的29%。单纯疱疹病毒（HSV）和肠道病毒各占11%，甲型流感病毒占7%。VZV似乎在中枢神经系统病毒感染中起主要作用。在我们研究的人群中发生的脑炎中，VZV显然比HSV更常与这些神经系统疾病相关。VZV感染迹象的增加部分可能是由于诊断方法改进导致的假现象，然而，也可能确实出现了增加，对此背后的发病机制应予以阐明。
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