绝经后雌激素缺乏对皮肤胶原蛋白的影响。

Effects of postmenopausal hypoestrogenism on skin collagen.

作者信息

Affinito P, Palomba S, Sorrentino C, Di Carlo C, Bifulco G, Arienzo M P, Nappi C

机构信息

Clinical Department of Gynecology, Obstetrics and Pathophysiology of Human Reproduction, University of Naples Federico II, Italy.

出版信息

Maturitas. 1999 Dec 15;33(3):239-47. doi: 10.1016/s0378-5122(99)00077-8.

DOI:10.1016/s0378-5122(99)00077-8

PMID:10656502

Abstract

OBJECTIVE

The aim of our study was to evaluate the effect of aging and postmenopausal hypoestrogenism on skin collagen content.

METHODS

Thirty-two women (mean age 48.78 +/- 9.86; year +/- S.D., range 28-68), 14 in premenopause and 18 in postmenopause, underwent skin biopsies performed during laparotomic operation. The amount of collagen type I, III and type III/type I ratio was evaluated by immunohistochemistry and computerised image analysis, and was related to age and years of postmenopause.

RESULTS

In the postmenopausal patients, a significant (P < 0.01) decrease of percentage of skin collagen type I, type III and type III/type I ratio was observed in comparison to premenopausal women. The percentages of collagen type I, type III and type III/I ratio of all patients studied was significantly (P < 0.01) correlated with chronological age (r = 0.88, 0.89 and 0.61, respectively). Considering only postmenopausal subjects, the correlation with chronological age was significant (P < 0.01) for collagen type I and type III of postmenopausal women (r = 0.59, r = 0.64, respectively), but not for the type III/I ratio (r = 0.37, P = 0.131). The percentages of collagen type I, type III and type III/I ratio of postmenopausal women showed a significant (P < 0.01) inverse correlation with years of postmenopause (r = 0.76, 0.73 and 0.73, respectively).

CONCLUSIONS

Our data suggest that the decrease of skin collagen is an estrogen-related phenomenon.

摘要

目的

本研究旨在评估衰老及绝经后雌激素缺乏对皮肤胶原含量的影响。

方法

32名女性（平均年龄48.78±9.86岁；岁±标准差，范围28 - 68岁），其中14名处于绝经前，18名处于绝经后，在开腹手术期间接受皮肤活检。通过免疫组织化学和计算机图像分析评估Ⅰ型、Ⅲ型胶原蛋白的含量及Ⅲ型/Ⅰ型比例，并将其与年龄及绝经年限相关联。

结果

与绝经前女性相比，绝经后患者皮肤中Ⅰ型、Ⅲ型胶原蛋白百分比及Ⅲ型/Ⅰ型比例显著降低（P < 0.01）。所有研究患者的Ⅰ型、Ⅲ型胶原蛋白百分比及Ⅲ型/Ⅰ型比例与实际年龄显著相关（P < 0.01）（r分别为0.88、0.89和0.61）。仅考虑绝经后受试者，绝经后女性的Ⅰ型和Ⅲ型胶原蛋白与实际年龄的相关性显著（P < 0.01）（r分别为0.59和0.64），但Ⅲ型/Ⅰ型比例与实际年龄无显著相关性（r = 0.37，P = 0.131）。绝经后女性的Ⅰ型、Ⅲ型胶原蛋白百分比及Ⅲ型/Ⅰ型比例与绝经年限呈显著负相关（P < 0.01）（r分别为0.76、0.73和0.73）。