多巴胺D(2)受体核酶抑制喹吡罗诱导的大鼠刻板行为。
Dopamine D(2) receptor ribozyme inhibits quinpirole-induced stereotypy in rats.
作者信息
Salmi P, Sproat B S, Ludwig J, Hale R, Avery N, Kela J, Wahlestedt C
机构信息
Center for Genomics Research, Karolinska Institutet, 171 77, Stockholm, Sweden.
出版信息
Eur J Pharmacol. 2000 Jan 24;388(1):R1-2. doi: 10.1016/s0014-2999(99)00866-3.
Abstract
The injection of a dopamine D(2) receptor hammerhead ribozyme (20 microg) once daily for 5 days into the nucleus accumbens of rats resulted in an inhibition of stereotyped sniffing and locomotor activation produced by the selective dopamine D(2) receptor agonist, quinpirole (0.4 mg kg(-1) s.c.). The results suggest that ribozymes may be useful in the study of in vivo gene function in the brain.
摘要
每天一次向大鼠伏隔核注射多巴胺D(2)受体锤头状核酶（20微克），持续5天，结果抑制了由选择性多巴胺D(2)受体激动剂喹吡罗（0.4毫克/千克皮下注射）产生的刻板嗅探和运动激活。结果表明，核酶可能有助于大脑中体内基因功能的研究。
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