Moss T J, Harding R
Fetal and Neonatal Research Unit, Department of Physiology, Monash University, Clayton, Victoria 3168, Australia.
J Appl Physiol (1985). 2000 Feb;88(2):641-8. doi: 10.1152/jappl.2000.88.2.641.
We have examined the effects of exposure to chronic maternal anemia, throughout the final one-third of gestation, on postnatal ventilatory and arousal responses to hypoxia, hypercapnia, and combined hypoxia-hypercapnia in sleeping lambs. While resting quietly awake, lambs from anemic ewes had higher arterial PCO(2) levels than control animals during the first 2-3 postnatal wk, but pH, arterial PO(2), and arterial O(2) saturation were not different. During active and quiet sleep lambs from anemic ewes had higher end-tidal CO(2) levels than control animals when breathing room air and at the time of spontaneous arousal or when aroused by progressive hypercapnia or by combined hypoxia-hypercapnia. Ventilation and arterial O(2) saturation during uninterrupted sleep and ventilatory responsiveness to hypoxia (inspiratory O(2) fraction, 10%), progressive hypercapnia, and combined hypoxia/hypercapnia were not significantly affected by exposure to maternal anemia. Our findings show that maternal anemia results in elevated PCO(2) levels in the offspring. This effect may be due, at least in part, to altered pulmonary function.
我们研究了在妊娠最后三分之一阶段持续暴露于母体贫血对出生后睡眠中小羊对低氧、高碳酸血症以及低氧-高碳酸血症联合刺激的通气和觉醒反应的影响。在安静清醒休息时，贫血母羊所产羔羊在出生后前2至3周的动脉血二氧化碳分压水平高于对照动物，但pH值、动脉血氧分压和动脉血氧饱和度并无差异。在主动睡眠和安静睡眠期间，贫血母羊所产羔羊在呼吸室内空气时、自发觉醒时、或因渐进性高碳酸血症或低氧-高碳酸血症联合刺激而觉醒时，其呼气末二氧化碳水平高于对照动物。不间断睡眠期间的通气和动脉血氧饱和度以及对低氧（吸入氧分数为10%）、渐进性高碳酸血症和低氧/高碳酸血症联合刺激的通气反应性并未因暴露于母体贫血而受到显著影响。我们的研究结果表明，母体贫血会导致后代的二氧化碳分压水平升高。这种影响可能至少部分归因于肺功能的改变。
