Wu C, Siems W F, Hill H H
Department of Chemistry, Washington State University, Pullman 99164-4630, USA.
Anal Chem. 2000 Jan 15;72(2):396-403. doi: 10.1021/ac9907235.
A secondary electrospray ionization (SESI) method was developed as a nonradioactive ionization source for ion mobility spectrometry (IMS). This SESI method relied on the gas-phase interaction between charged particles created by electrospray ionization (ESI) and neutral gaseous sample molecules. Mass spectrometry (MS) was used as the detection method after ion mobility separation for ion identification. Preliminary investigations focussed on understanding the ionization process of SESI. The performance of ESI-IMS and SESI-IMS for illicit drug detection was evaluated by determining the analytical figures of merit. In general, SESI had a higher ionization efficiency for small volatile molecules compared with the electrospray method. The potential of developing a universal interface for both GC- and LC-MS with an addition stage of mobility separation was demonstrated.
开发了一种二次电喷雾电离（SESI）方法作为离子迁移谱（IMS）的非放射性电离源。这种SESI方法依赖于电喷雾电离（ESI）产生的带电粒子与中性气态样品分子之间的气相相互作用。离子迁移分离后，使用质谱（MS）作为检测方法进行离子鉴定。初步研究集中在理解SESI的电离过程。通过确定性能指标评估了ESI-IMS和SESI-IMS用于非法药物检测的性能。一般来说，与电喷雾方法相比，SESI对小挥发性分子具有更高的电离效率。展示了开发用于气相色谱和液相色谱-质谱联用且增加迁移分离阶段的通用接口的潜力。
