College of Science, Beijing Key Laboratory of Environmentally Harmful Chemical Analysis, Beijing University of Chemical Technology, Beijing, China.
College of Science, Beijing Key Laboratory of Environmentally Harmful Chemical Analysis, Beijing University of Chemical Technology, Beijing, China.
Talanta. 2018 Jul 1;184:65-72. doi: 10.1016/j.talanta.2018.02.086. Epub 2018 Mar 29.
Ion mobility spectrometry (IMS) which acts as a rapid analysis technique is widely used in the field detection of illicit drugs and explosives. Due to limited separation abilities of the pint-sized IMS challenges and problems still exist regarding high false positive and false negative responses due to the interference of the matrix. In addition, the gas-phase ion chemistry and special phenomena in the IMS spectra, such one substance showing two peaks, were not identified unambiguously. In order to explain or resolve these questions, in this paper, an ion mobility spectrometry was coupled to a mass spectrometry (IMS-MS). A commercial IMS is embedded in a custom-built ion chamber shell was attached to the mass spectrometer. The faraday plate of IMS was fabricated with a hole for the ions to passing through to the mass spectrometer. The ion transmission efficiency of IMS-MS was optimized by optimizing the various parameters, especially the distance between the faraday plate and the cone of mass spectrum. This design keeps the integrity of the two original instruments and the mass spectrometry still works with multimode ionization source (i.e., IMS-MS, ESI-MS, APCI-MS modes). The illicit drugs and explosive samples were analyzed by the IMS-MS with Ni source. The results showed that the IMS-MS is of high sensitivity. The ionization mechanism of the illicit drug and explosive samples with Ni source were systematically studied. In addition, the interferent which interfered the detection of cocaine was identified as dibutyl phthalate (DBP) by this platform. The reason why the acetone solution of amphetamine showed two peaks was explained.
离子迁移谱（IMS）作为一种快速分析技术，在非法药物和爆炸物的现场检测中得到了广泛应用。由于小型 IMS 的分离能力有限，由于基质的干扰，仍然存在高假阳性和假阴性反应的问题。此外，IMS 光谱中的气相离子化学和特殊现象，例如一种物质显示两个峰，尚未明确识别。为了解释或解决这些问题，在本文中，将离子迁移谱（IMS）与质谱（IMS-MS）进行了耦合。将商业 IMS 嵌入定制的离子室外壳中，并将其连接到质谱仪上。IMS 的法拉第板上开有一个孔，让离子通过进入质谱仪。通过优化各种参数，特别是法拉第板和质谱锥之间的距离，优化了 IMS-MS 的离子传输效率。这种设计保持了两个原始仪器的完整性，质谱仪仍然可以使用多模式电离源（即 IMS-MS、ESI-MS、APCI-MS 模式）工作。通过 IMS-MS 用镍源分析了非法药物和爆炸物样品。结果表明，IMS-MS 具有很高的灵敏度。系统研究了镍源对非法药物和爆炸物样品的电离机制。此外，通过该平台鉴定出干扰可卡因检测的干扰物为邻苯二甲酸二丁酯（DBP）。解释了为什么乙腈溶液中的苯丙胺显示两个峰。
