Nagai H, Suzuki T, Katsumata N, Iwasaki K, Ogawa S, Suzuki H
Department of Anesthesiology, University Hospital, Tokyo.
Masui. 1999 Dec;48(12):1294-301.
We investigated the effect of d-tubocurarine (d-Tc), pancuronium (PAN), vecuronium (VEC), and rocuronium (ROC) on the autonomic nervous system in cats by measuring changes in the invasive mean arterial pressure (MAP), heart rate (HR), and heart rate variability following four administrations of each drug at 2.ED95. Heart rate variability analysis was used to assess the effects of the drugs on sympathetic and parasympathetic nervous system function using low-frequency (0.04-0.22 Hz) component (LF) and high-frequency (0.22-0.60 Hz) component (HF). Comparisons of the HR, MAP, LF, HF, and LF/HF ratio before and after drug administration were made for each drug. The administration of d-Tc caused a significant decrease in MAP and a significant increase in HR accompanied by increase in LF, HF, and LF/HF ratio. The increases in the LF, HF and LF/HF ratio appeared to be related to the mean abrupt enhancement of sympathetic and parasympathetic nervous system function caused by changes in circulatory dynamics. PAN caused a significant increase in HR, and a significant decrease in the HF, which we thought were related to suppression of cardiac parasympathetic function. Neither VEC nor ROC produced a significant change in any of the parameters and were considered to have no significant effect on the autonomic nervous system.
我们通过测量在2倍等效剂量95（2.ED95）下每种药物四次给药后有创平均动脉压（MAP）、心率（HR）和心率变异性的变化，研究了筒箭毒碱（d-Tc）、泮库溴铵（PAN）、维库溴铵（VEC）和罗库溴铵（ROC）对猫自主神经系统的影响。心率变异性分析用于使用低频（0.04 - 0.22赫兹）成分（LF）和高频（0.22 - 0.60赫兹）成分（HF）评估药物对交感神经和副交感神经系统功能的影响。对每种药物给药前后的HR、MAP、LF、HF和LF/HF比值进行了比较。d-Tc给药导致MAP显著降低，HR显著升高，同时LF、HF和LF/HF比值增加。LF、HF和LF/HF比值的增加似乎与循环动力学变化引起的交感神经和副交感神经系统功能的平均突然增强有关。PAN导致HR显著增加，HF显著降低，我们认为这与心脏副交感神经功能的抑制有关。VEC和ROC均未使任何参数产生显著变化，被认为对自主神经系统无显著影响。
