Schroter R C, Leeming A, Denny E, Bharath A, Marlin D J
Department of Biological and Medical Systems, Imperial College of Science, Technology and Medicine, London, UK.
Equine Vet J Suppl. 1999 Jul(30):34-8. doi: 10.1111/j.2042-3306.1999.tb05184.x.
Recently we proposed that exercise-induced pulmonary haemorrhage (EIPH) results from locomotory-impact-induced trauma by impact of the scapula on the chest wall during footfall and the consequent transmission of waves through the lung. A computational model has been developed to demonstrate that wave amplification and focusing occur in the dorsocaudal tip of the lung for waves originating on the anterior subscapular surface. The propagation of an acoustic wave was investigated in a simplified 2-dimensional representation of a vertical anterio-dorsal section of horse lung. It was demonstrated that a complicated pattern of waves is transmitted from the scapula to the dorsal region. Wave motion was characterised using the instantaneous rate of change of pressure with time (dp/dt) which is associated with lung injury. Due to wave reflection and focusing, dp/dt is transiently very high on the spinal and diaphragmatic lung walls, particularly in the vicinity of the dorsal tip. The model therefore predicts that lung injury may occur in the region in which EIPH is reported to originate.
最近我们提出，运动性肺出血（EIPH）是由于在脚步落地时肩胛骨撞击胸壁导致的运动冲击性创伤以及随后波在肺内的传播所致。已经开发了一个计算模型来证明，对于起源于肩胛下前表面的波，在肺的背尾端会发生波的放大和聚焦。在马肺垂直前后背侧截面的简化二维表示中研究了声波的传播。结果表明，复杂的波型从肩胛骨传播到背部区域。使用与肺损伤相关的压力随时间的瞬时变化率（dp/dt）来表征波动。由于波的反射和聚焦，dp/dt在脊柱和膈肌肺壁上会瞬时变得非常高，特别是在背端附近。因此，该模型预测肺损伤可能发生在据报道EIPH起源的区域。
