Makimoto Y, Sugiyama T, Kojima S, Azuma I
Department of Ophthalmology, Osaka Medical College, Takatsuki, Japan.
Nippon Ganka Gakkai Zasshi. 2000 Jan;104(1):39-43.
To study the long-term effect of topically applied 0.12% isopropyl unoprostone (unoprostone, Rescula) on microcirculation in the ocular fundus.
Using a laser speckle tissue circulation analyzer, normalized blur (NB), a quantitative index of blood flow velocity and tissue blood flow, was measured in the optic nerve head (ONH) and choroid-retina before and 4.5 hours after an instillation of placebo into both eyes in 11 normal human volunteers. Intraocular pressure (IOP), blood pressure, and pulse rate were also measured. A drop of unoprostone or the placebo was instilled into each eye in a double-blind manner twice a day for 21 days (the treated or untreated eye).
Twenty-one days later, NB values in the ONH and the choroid-retina increased significantly and the IOP decreased significantly only in the treated eyes. Ocular perfusion pressure showed no significant changes.
These results suggest that the increase of the blood flow in the microcirculation in the human ocular fundus following the relatively long-term topical application of unoprostone may be due to reduction in vascular resistance.
研究局部应用0.12%异丙基乌诺前列酮（乌诺前列酮，Rescula）对眼底微循环的长期影响。
使用激光散斑组织循环分析仪，在11名正常人类志愿者双眼滴入安慰剂前及滴入后4.5小时，测量视神经乳头（ONH）和脉络膜 - 视网膜的归一化模糊度（NB），这是血流速度和组织血流量的定量指标。还测量了眼压（IOP）、血压和脉搏率。以双盲方式每天两次向每只眼睛滴入一滴乌诺前列酮或安慰剂，持续21天（治疗眼或未治疗眼）。
21天后，仅治疗眼的ONH和脉络膜 - 视网膜中的NB值显著增加，眼压显著降低。眼灌注压无显著变化。
这些结果表明，相对长期局部应用乌诺前列酮后，人眼底微循环血流量增加可能是由于血管阻力降低。
