咖啡因对人眼底微循环的影响。

Effects of caffeine on microcirculation of the human ocular fundus.

作者信息

Okuno Takashi, Sugiyama Tetsuya, Tominaga Mika, Kojima Shota, Ikeda Tsunehiko

机构信息

Department of Ophthalmology, Osaka Medical College, Takatsuki, Osaka, Japan.

出版信息

Jpn J Ophthalmol. 2002 Mar-Apr;46(2):170-6. doi: 10.1016/s0021-5155(01)00498-1.

DOI:10.1016/s0021-5155(01)00498-1

PMID:12062222

Abstract

PURPOSE

To determine the effect of caffeine on microcirculation in the human ocular fundus.

METHODS

The microcirculation in the ocular fundus of 10 healthy volunteers (10 eyes) was studied using a laser speckle tissue circulation analyzer. Caffeine or placebo (100 mg) was administered orally in a double-masked manner. Square blur rate (SBR), a quantitative index of blood flow velocity, was measured in a temporal site of the optic nerve head (ONH) free of surface vessels and in a middle site of the choroid-retina between the ONH and macula. Intraocular pressure (IOP), blood pressure (BP), pulse rate (PR), and central critical fusion frequency (CFF) were also measured. These parameters were measured before and for 2 hours after administration. The area under curve (AUC) of SBR was calculated for each area. Ocular perfusion pressure (OPP) was also calculated from BP and IOP.

RESULTS

The time-course of change in SBR value showed much individual difference. Caffeine decreased the AUC of SBR in the ONH (P =.0218) as well as in the choroid-retina (P =.0469) significantly. IOP, mean BP, PR, OPP, and central CFF did not change significantly.

CONCLUSIONS

These results suggest that caffeine may increase blood vessel resistance and decrease blood flow in the human ONH and choroid-retina.

摘要

目的

确定咖啡因对人眼底微循环的影响。

方法

使用激光散斑组织循环分析仪研究10名健康志愿者（10只眼）的眼底微循环。以双盲方式口服咖啡因或安慰剂（100毫克）。在视神经乳头（ONH）无表面血管的颞侧部位以及ONH与黄斑之间的脉络膜 - 视网膜中间部位测量血流速度的定量指标——方形模糊率（SBR）。还测量眼压（IOP）、血压（BP）、脉搏率（PR）和中枢临界融合频率（CFF）。在给药前和给药后2小时测量这些参数。计算每个区域SBR的曲线下面积（AUC）。还根据BP和IOP计算眼灌注压（OPP）。