Druss B G, Bradford D W, Rosenheck R A, Radford M J, Krumholz H M
Department of Psychiatry, Yale University School of Medicine, VA Northeast Program Evaluation Center, New Haven, Conn, USA.
JAMA. 2000 Jan 26;283(4):506-11. doi: 10.1001/jama.283.4.506.
A number of studies have found race- and sex-based differences in rates of cardiovascular procedures in the United States. Similarly, mental disorders might be expected to be associated with lower rates of such procedures on the basis of clinical, socioeconomic, patient, and provider factors.
To assess whether having a comorbid mental disorder is associated with a lower likelihood of cardiac catheterization and/or revascularization after acute myocardial infarction.
Retrospective cohort study using data from medical charts and administrative files as part of the Cooperative Cardiovascular Project.
Acute care nongovernmental hospitals in the United States.
National cohort of 113653 eligible patients 65 years or older who were hospitalized for confirmed acute myocardial infarction between February 1994 and July 1995.
Likelihood of cardiac catheterization, percutaneous transluminal coronary angioplasty (PTCA), or coronary artery bypass graft (CABG) surgery during the index hospitalization, comparing patients with and without mental disorders (classified as schizophrenia, major affective disorder, substance abuse/dependence disorder, or other mental disorder).
Compared with the remainder of the sample, patients with any comorbid mental disorder (n = 5365; 4.7%) were significantly less likely to undergo PTCA (11.8% vs 16.8%; P<.001) or CABG (8.2% vs 12.6%; P<.001). After adjusting for demographic, clinical, hospital, and regional factors, individuals with mental disorders were 41% (for schizophrenia) to 78% (for substance use) as likely to undergo cardiac catheterization as those without mental disorders (P<.001 for all). Among those undergoing catheterization, rates of PTCA or CABG for patients with mental disorders were not significantly different from rates for patients without mental disorders (for those with any mental disorder, P = .12 for PTCA and P = .06 for CABG). In multivariate models, the 30-day mortality did not differ between patients with and without mental disorders.
In this study, individuals with comorbid mental disorders were substantially less likely to undergo coronary revascularization procedures than those without mental disorders. Further research is needed to understand the degree to which patient and provider factors contribute to this difference and its implications for quality and long-term outcomes of care.
多项研究发现,在美国,心血管疾病治疗率存在基于种族和性别的差异。同样,基于临床、社会经济、患者和医疗服务提供者等因素,精神障碍可能与较低的此类治疗率相关。
评估急性心肌梗死后合并精神障碍是否与接受心脏导管插入术和/或血运重建术的可能性较低有关。
采用合作心血管项目中来自病历和管理档案的数据进行回顾性队列研究。
美国的非政府急性护理医院。
1994年2月至1995年7月期间因确诊急性心肌梗死住院的113653名65岁及以上符合条件患者的全国队列。
在本次住院期间进行心脏导管插入术、经皮腔内冠状动脉成形术(PTCA)或冠状动脉旁路移植术(CABG)手术的可能性,比较有精神障碍(分类为精神分裂症、重度情感障碍、物质滥用/依赖障碍或其他精神障碍)和无精神障碍的患者。
与样本中的其他患者相比,任何合并精神障碍的患者(n = 5365;4.7%)接受PTCA(11.8%对16.8%;P <.001)或CABG(8.2%对12.6%;P <.001)的可能性显著较低。在调整了人口统计学、临床、医院和地区因素后,有精神障碍的个体接受心脏导管插入术的可能性是无精神障碍个体的41%(精神分裂症患者)至78%(物质使用障碍患者)(所有P <.001)。在接受导管插入术的患者中,有精神障碍患者的PTCA或CABG率与无精神障碍患者的率无显著差异(对于任何精神障碍患者,PTCA的P = 0.12,CABG的P = 0.06)。在多变量模型中,有精神障碍和无精神障碍患者的30天死亡率无差异。
在本研究中,合并精神障碍的个体接受冠状动脉血运重建术的可能性明显低于无精神障碍的个体。需要进一步研究以了解患者和医疗服务提供者因素在多大程度上导致了这种差异及其对护理质量和长期结果的影响。