Navarro J F, Velasco R, Manzaneque J M
Area de Psicobiología, Facultad de Psicología, Universidad de Málaga, Spain.
Prog Neuropsychopharmacol Biol Psychiatry. 2000 Jan;24(1):131-42. doi: 10.1016/s0278-5846(99)00076-7.
The aim of this study was to examine the effects of pimozide (0.25-1.25 mg/kg), administered acutely or subchronically for 10 days, on agonistic behavior elicited by isolation in male mice. Individually housed mice were exposed to anosmic "standard opponents" 90 min after pimozide injections, and the encounters were videotaped and evaluated using an ethologically based analysis. 3. After acute treatment pimozide did not affect significantly aggression and immobility. However, mice treated subchronically with pimozide (0.75 and 1.25 mg/kg) showed a significant reduction in offensive behaviors (threat and attack) and an increase of immobility (1.25 mg/kg). The antiaggressive and motor actions of pimozide were more marked after subchronic treatment than after acute treatment. It might reflect an accumulation of the drug over time, an effect also described with other neuroleptics such as amisulpride.
本研究的目的是考察急性或连续10天亚慢性给予匹莫齐特（0.25 - 1.25毫克/千克）对雄性小鼠隔离诱发的攻击行为的影响。单独饲养的小鼠在注射匹莫齐特90分钟后接触无嗅觉的“标准对手”，并对相遇情况进行录像，采用基于行为学的分析方法进行评估。3. 急性治疗后，匹莫齐特对攻击行为和不动行为无显著影响。然而，亚慢性给予匹莫齐特（0.75和1.25毫克/千克）的小鼠攻击性（威胁和攻击）行为显著减少，不动行为增加（1.25毫克/千克）。与急性治疗相比，亚慢性治疗后匹莫齐特的抗攻击和运动作用更明显。这可能反映了药物随时间的积累，其他抗精神病药物如氨磺必利也有类似作用。
