Yamada Y, Sugahara K, Tsuruda K, Nohda K, Hata T, Maeda T, Honda M, Tawara M, Hayashibara T, Joh T, Tomonaga M, Miyazaki Y, Kamihira S
Department of Laboratory Medicine, Nagasaki University School of Medicine, Japan.
Cancer Lett. 1999 Dec 1;147(1-2):215-9. doi: 10.1016/s0304-3835(99)00313-4.
A preventive role for human T-cell leukemia virus type-I (HTLV-I) and Fas-associated phosphatase-1 (FAP-1) in Fas-mediated apoptosis has been reported in HTLV-I-infected cells. In the present study, we examined whether these molecules increased during the acquisition of Fas-resistance in adult T-cell leukemia (ATL) cell lines. SO4, ST1 and KK1 are Fas-sensitive ATL cell lines, and produce small amounts of HTLV-I in vitro. Although their subclones RSO4 and RST1 are completely Fas-resistant, they produced an equivalent amount of HTLV-I to SO4 and ST1. Moreover, FAP-1 mRNA was not detected in these cell lines irrespective of Fas sensitivity. Thus, Fas resistance in ATL cells was not directly associated with the increased production of HTLV-I or FAP-1.
