疑似人类致癌物2-氨基-1-甲基-6-苯基咪唑并[4,5-b]吡啶诱导的大鼠前列腺突变。
Prostate mutations in rats induced by the suspected human carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.
作者信息
Stuart G R, Holcroft J, de Boer J G, Glickman B W
机构信息
Centre for Environmental Health and Department of Biology, University of Victoria, British Columbia, Canada.
出版信息
Cancer Res. 2000 Jan 15;60(2):266-8.
Male lacl transgenic rats were fed a diet containing 200 ppm of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), a heterocyclic amine present in cooked meats. PhIP was found to be a powerful prostate mutagen. After 61 days of treatment, the lacl mutant frequency was 71 x 10(-5), >20-fold higher than the spontaneous mutant frequency of 3.2 x 10(-5). The predominant PhIP-induced mutations were G:C->T:A transversions and deletions of G:C bp. The results directly link PhIP-induced mutations with the earlier observation of PhIP-induced prostate cancer in rats and suggest that exposure to dietary PhIP could be a risk factor in the incidence of human prostate cancer.
给雄性lacl转基因大鼠喂食含有200 ppm 2-氨基-1-甲基-6-苯基咪唑并[4,5-b]吡啶（PhIP）的饮食，PhIP是一种存在于熟肉中的杂环胺。已发现PhIP是一种强大的前列腺诱变剂。治疗61天后，lacl突变频率为71×10⁻⁵，比自发突变频率3.2×10⁻⁵高20倍以上。PhIP诱导的主要突变是G:C→T:A颠换和G:C碱基对的缺失。这些结果直接将PhIP诱导的突变与早期在大鼠中观察到的PhIP诱导的前列腺癌联系起来，并表明饮食中接触PhIP可能是人类前列腺癌发病的一个风险因素。
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